*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QS4476800
CHEMICAL NAME           : Nicotinamide, N-(2-indol-3-ylethyl)-
CAS REGISTRY NUMBER     : 29876-14-0
BEILSTEIN REFERENCE NO. : 0242441
REFERENCE               : 5-22-10-00125 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H15-N3-O
MOLECULAR WEIGHT        : 265.34
WISWESSER LINE NOTATION : T56 BMJ D2MV- CT6NJ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * N-(2-(3-Indolyl)ethyl)-nicotinamide
   * N-(2-Indol-3-ylethyl)nicotinamide
   * N-(2-(1H-Indol-3-yl)ethyl)-3-pyridinecarboxamide
   * N-Nicotinoyltryptamide
   * 3-Pyridinecarboxamide, N-(2-(1H-indol-3-yl)ethyl)-
   * N-3-Pyridoyltryptamine
   * Tryptamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae.  (Warsaw, Poland)
   V.18-24, 1966-72.  For publisher information, see PJPPAA.
   Volume(issue)/page/year: 22,313,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 90 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   39,779,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4500 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   39,779,1987
 
                            *** END OF RECORD ***