*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QU1985500
CHEMICAL NAME           : Nipecotic acid, 1-((2-hydroxy-1-naphthyl)methyl)-,
                          ethyl ester
CAS REGISTRY NUMBER     : 108984-35-6
BEILSTEIN REFERENCE NO. : 0293703
REFERENCE               : 4-22-00-00124 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C19-H23-N-O3
MOLECULAR WEIGHT        : 313.43
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-(3'-Ethoxycarbonylpiperidinomethyl)-2-naphthol
   * 1-((2-Hydroxy-1-naphthyl)methyl)nipecotic acid ethyl ester
   * Ro 3-0570
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 168 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 12,194,1957
 
                            *** END OF RECORD ***