*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QT2275000
CHEMICAL NAME           : Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl
                          ester, hydrobromide
CAS REGISTRY NUMBER     : 300-08-3
LAST UPDATED            : 199012
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H13-N-O2.Br-H
MOLECULAR WEIGHT        : 236.14
WISWESSER LINE NOTATION : T6N CUTJ A1 CVO1 &EH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Arecoline bromide
   * Arecoline hydrobromide
   * Arekolinhydrobromid
   * Methyl 1,2,5,6-tetrahydro-1-methylnicotinate, hydrobromide
   * N-Methyltetrahydronicotinic acid methyl ester hydrobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   28,681,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 35,75,1929
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#11778
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   28,681,1972
 
                            *** END OF RECORD ***