*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QS4375000
CHEMICAL NAME : Nicotinamide, N,N-diethyl-
CAS REGISTRY NUMBER : 59-26-7
BEILSTEIN REFERENCE NO. : 0005743
REFERENCE : 5-22-02-00084 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C10-H14-N2-O
MOLECULAR WEIGHT : 178.26
WISWESSER LINE NOTATION : T6NJ CVN2&2
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Anacardone
* Anacordone
* Astrocar
* Canfodiamina
* Camphozone
* Carbamidal
* Cardamine
* Cardiagen
* Cardiamid
* Cardiamina
* Cardiamine
* Cardimon
* Coracon
* Coraethamide
* Coraethamidum
* Coralept
* Coramine
* Coravita
* Corazone
* Cordiamid
* Cordiamin
* Cordiamine
* Corditon
* Cordynil
* Corediol
* Corespin
* Corethamide
* Coretone
* Cormed
* Cormid
* Cormotyl
* Cornotone
* Corotonin
* Corovit
* Corvitan
* Corvitol
* Corvotone
* Corywas
* Danamine
* Diaethyl-nicotinamid
* Diethylamid kyseliny nikotinove
* Diethyl-nicotamide
* N,N-Diethylnicotinamide
* N,N-Diethyl-3-pyridinecarboxamide
* Dietilamide-carbopiridina
* Dinacoryl
* Dynacoryl
* Dynamicarde
* Elitone
* Eucoran
* Hansacor
* Inicardio
* Kardiamid
* Kardonyl
* Kordiamin
* Leptamin
* Mediamid
* Niamine
* Nicamide
* Nicetamide
* Nicethamide
* Nicor
* Nicordamin
* Nicorine
* Nicoryl
* Nicotinic acid diethylamide
* Nikardin
* Niketamid
* Nikethamide
* Niketharol
* Nikethyl
* Niketilamid
* Nikorin
* Nikotin
* Niquetamida
* Nisetamide
* Percoral
* Procardine
* Procorman
* Pyricardyl
* Pyridine-3-carboxydiethylamide
* Pyridine-3-carboxylic acid diethylamide
* Reformin
* Rehormin
* Salvacard
* Salvacorin
* Stellamine
* Stiminol
* Stimulin
* Tonocor
* Ventramine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 272 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 4,132,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 240 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 62,19,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 191 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,173,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 188 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - rigidity (including catalepsy)
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
1,423,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 174 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 128,176,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
111,293,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 85,305,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 288 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
53,2S,1957
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
12,1860,1933
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 66,260,1939
*** END OF RECORD ***