*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QR8925000
CHEMICAL NAME           : Nickel refinery dust
SUBSTANCE DEFINITION :
   Analysis: cupric oxide(3.4%), nickel sulfate(20.0%), nickel sulfide(57.0%),
   nickel oxide(6.3%), cobalt oxide(1.0%), ferric oxide(1.8%), silicon
   dioxide(1.2%), misc.(2.0%), water(7.3%)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,158,1962
LAST UPDATED            : 199712
DATA ITEMS CITED        : 34
COMPOUND DESCRIPTOR     : Tumorigen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,152,1962
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,152,1962
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,152,1962

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 1 mg(Ni)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   IARC Cancer Review:Human Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 2,126,1973

   IARC Cancer Review:Group 1
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,264,1987

   TOXICOLOGY REVIEW
   ACLSCP Annals of Clinical and Laboratory Science.  (1833 Delancey Pl.,
   Philadelphia, PA 19103) V.1-    1971-  Volume(issue)/page/year: 3,156,1973

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
   
   OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993
   
   OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993
   
   OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993
   
   OEL-GERMANY;Carcinogen JAN 1993
   
   OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993
   
   OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
   
   OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993
   
   OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993
   
   OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***