*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QN2792160
CHEMICAL NAME           : 1,8-Naphthyridine-3-carboxylic acid,
                          1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(4-
                          fluorophenyl)-5-methyl-4-oxo-, hydrochloride, hydrate
                          (1:1:1), (S)-
CAS REGISTRY NUMBER     : 138668-61-8
LAST UPDATED            : 199312
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H18-F2-N4-O3.Cl-H.H2-O
MOLECULAR WEIGHT        : 454.90
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 35,518,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 35,518,1992
 
                            *** END OF RECORD ***