*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QM7000000
CHEMICAL NAME           : 1,3,5-Naphthylenetrisulfonic acid,
                          8,8'-(ureylenebis(m-phenylenecarbonylimino(4-methyl-
                          m-phenylene)carbonylimino))di-, hexasodium salt
CAS REGISTRY NUMBER     : 129-46-4
LAST UPDATED            : 199512
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C51-H34-N6-O23-S6.6Na
MOLECULAR WEIGHT        : 1429.21
WISWESSER LINE NOTATION : L66J BSWQ DSWQ GSWQ JMVR D1 CMVR CMVMR CVMR B1 EVM-
                          JL66J BSWQ DSWQ GSWQ &-NA- 6
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Antrypol
   * BAY 205
   * Bayer 205
   * 1-(3-Benzamido-4-methylbenzamido)naphthalene-4,6,8-trisulfonic acid  
   sym-3''-urea sodium salt
   * 309 F
   * Fourneau 309
   * Germanin
   * Moranyl
   * Naganin
   * Naganine
   * Naphuride sodium
   * NF060
   * Sodium suramin
   * Suramine sodium
   * Suramin sodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 136,64,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,1423,1989
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 252 mg/kg/7W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   IVIVE4 In Vivo.  (POB 51359, Kiffisia, GR-145 10, Greece)  V.1-    1987-
   Volume(issue)/page/year: 6,617,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1750 mg/kg/7D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 136,64,1986
 
                            *** END OF RECORD ***