*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QK2450000
CHEMICAL NAME : 2-Naphthalenesulfonic acid,
6-hydroxy-5-((p-sulfophenyl)azo)-, disodium salt
CAS REGISTRY NUMBER : 2783-94-0
LAST UPDATED : 199707
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C16-H10-N2-O7-S2.2Na
MOLECULAR WEIGHT : 452.38
WISWESSER LINE NOTATION : L66J BNUNR DSWQ& CQ HSWQ &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acid Yellow TRA
* A.F. Yellow No. 5
* Aizen Food Yellow No. 5
* Alabaster No. 3
* Atul Sunset Yellow FCF
* Canacert Sunset Yellow FCF
* Certicol Sunset Yellow CFS
* C.I. 15985
* C.I. Food Yellow 3, disodium salt
* Cilefa Orange S
* Disodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acid
* Dolkwal Sunset Yellow
* E 110
* Edicol Supra Yellow FC
* Eniacid Sunset Yellow
* Eurocert Orange FCF
* FD and C No. 6
* FD and C Yellow 6
* FD and C Yellow No. 6
* Food Yellow 3
* Food Yellow 6
* Gelborange-S
* HD Sunset Yellow FCF
* HD Sunset Yellow FCF Supra
* Hexacol Sunset Yellow FCF
* Hexacol Sunset Yellow FCF Supra
* 6-Hydroxy-5-((p-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium
salt
* 6-Hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium
salt
* 6-Hydroxy-5-((p-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium
salt
* 6-Hydroxy-5-((4-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium
salt
* KCA Foodcol Sunset Yellow FCF
* L. Orange Z2010
* Maple Sunset Yellow FCF
* NCI-C53907
* Orange PAL
* Orange II R
* Orange Yellow S
* Orange Yellow S. AF
* Orange Yellow S. FQ
* Para Orange
* Standacol Sunset Yellow FCF
* 1-p-Sulfophenylazo-2-hydroxynaphthalene-6-sulfonate, disodium salt
* 1-p-Sulfophenylazo-2-naphthol-6-sulfonic acid, disodium salt
* 1-p-Sulphophenylazo-2-naphthol-6-sulphonic acid, disodium salt
* Sun Orange A Geigy
* Sunset Yellow
* Sunset Yellow FCF
* Sunset Yellow FCF Supra
* Sunset Yellow FU
* Sunset Yellow FU Supra
* Sunset Yellow Lake
* SUN Yellow
* SUN Yellow A-CE
* SUN Yellow A-FDC
* SUN Yellow Extra Conc. A Export
* SUN Yellow Extra Pure A
* SUN Yellow FCF
* Usacert Yellow No. 6
* Usacert FD&C Yellow No. 6
* 1351 Yellow
* 1899 Yellow
* Yellow No. 6
* Yellow Orange S
* Yellow Orange S Specially Pure
* Yellow Orange Specially Pure 85
* Yellow sun
* Yellow SY for food
* Zlut potravinarska 3
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >6 gm/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 243 gm/kg/96D-C
TOXIC EFFECTS :
Gastrointestinal - other changes
Related to Chronic Data - changes in testicular weight
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 476 mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 10,625,1958
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 1 gm/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
236,933,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 2 gm/L
REFERENCE :
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring
St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year:
27,95,1981
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,257,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,257,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For
publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2135
No. of Facilities: 2510 (estimated)
No. of Industries: 14
No. of Occupations: 21
No. of Employees: 17624 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2135
No. of Facilities: 11207 (estimated)
No. of Industries: 67
No. of Occupations: 62
No. of Employees: 195835 (estimated)
No. of Female Employees: 103566 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; In vitro
SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-208,81
*** END OF RECORD ***