*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QK1925000
CHEMICAL NAME : 1-Naphthalenesulfonic acid, 4-hydroxy-3,4'-azodi-,
disodium salt
CAS REGISTRY NUMBER : 3567-69-9
OTHER CAS REGISTRY NOS. : 65721-85-9
LAST UPDATED : 199703
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C20-H12-N2-O7-S2.2Na
MOLECULAR WEIGHT : 502.44
WISWESSER LINE NOTATION : L66J BSWQ ENUN- CL66J BQ ESWQ &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acetacid Red B
* Acid Brilliant Rubine A2G conc.
* Acid Brilliant Rubine 2G
* Acid Brilliant Rubine 2GT
* Acid Chrome Blue BA
* Acid Chrome Blue BA-CF
* Acid Chrome Blue FBS
* Acid Chrome Blue 2R
* Acid Fast Red FB
* Acid Red 14
* Acid Red 2C
* Acid Rubine
* Acid Rubine Extra
* Airedale carmoisine
* Amacid carmoisine B
* Amacid Chrome Blue R
* Atul Acid Crystal Red
* Atul Crystal Red F
* Azorubin
* Azo Rubin Extra
* Azo Rubine
* Azo Rubine AF
* Azo Rubine (biological stain)
* Azo Rubine Extra LC
* Azo Rubine for food
* Azo Rubine LZ
* Azo Rubine S
* Azo Rubine S Specially Pure
* Azo Rubine XX
* Azo rubin S
* Azo rubin XX
* Brasilan Azo Rubine 2NS
* Brilliant Acid Rubine M
* Brilliant carmoisine
* Brilliant Crimson Red
* Brilliant Crimson 2R. FQ
* Bucacid Azo Rubine
* Calcocid Rubine XX
* Carmoisin
* Carmoisine
* Carmoisine Aluminum Lake
* Carmoisine BA
* Carmoisine BA-CF
* Carmoisine BSS
* Carmoisine FU
* Carmoisine GRN
* Carmoisine LAS
* Carmoisine S
* Carmoisine Supra
* Carmoisine W
* Carmoisine WS
* Certicol carmoisine S
* Cerven kysela 14
* Cerven potravinarska 3
* Chrome Fast Blue 2R
* Chromotrop FB
* Chromotrope FB
* C.I. 14720
* C.I. Acid Red 14, disodium salt
* C.I. Food Red 3
* Cilefa Rubine R
* Crimson EMBL
* Crimson 2EMBL
* Diadem Chrome Blue G
* Diadem Chrome Blue R
* Disodium salt of 2-(4-sulpho-1-naphthylazo)-1-naphthol-4-sulphonic acid
* Disodium 2-(4-sulfo-1-naphthylazo)-1-naphthol-4-sulfonate
* Disodium 2-(4-sulpho-1-naphthylazo)-1-naphthol-4-sulphonate
* E122
* Edicol Supra Carmoisine W
* Edicol Supra Carmoisine WS
* Eniacid Brilliant Rubine 3B
* Erio Rubine B
* Eurocert Azorubine
* Ext D & C Red No. 10
* Extract D and C Red No. 10
* Fenazo Red C
* Food Red 5
* Fruit Red A Extra Yellowish Geigy
* HD carmoisine
* HD Carmoisine Supra
* Hexacol carmoisine
* Hexacol carmoisine conc.
* Hidacid Azo Rubine
* Hispacid Rubine F
* 4-Hydroxy-3,4'-azodi-1-naphthalenesulfonic acid, disodium salt
* 4-Hydroxy-3,4'-azodi-1-naphthalenesulphonic acid, disodium salt
* 4-Hydroxy-3-((4-sulfo-1-naphthalenyl)azo)-1-naphthalenesulfonic acid,
disodium salt
* 4-Hydroxy-3-((4-sulpho-1-naphthalenyl)azo)-1-naphthalenesulphonic acid,
disodium salt
* Java Rubine N
* Karmesin
* Kenachrome Blue 2R
* Kiton Crimson 2R
* Kiton Rubine R
* Lighthouse Chrome Blue 2R
* L. Red Z 3040
* Nacarat
* Nacarat A export
* Nacarat Extra Pure A
* NCI-C53849
* Neklacid Azorubine W
* Neklacid Rubine W
* Nylomine Acid Red P4B
* Omega Chrome Blue FB
* Pontacyl Rubine R
* Poloxal Red 2B
* Red #14
* 11959 Red
* Schultz Nr. 208
* Solar Rubine
* Solochrome Blue FB
* Standacol carmoisine
* 2-(4-Sulfo-1-naphthylazo)-1-naphthol-4-sulfonic acid, disodium salt
* 2-(4-Sulpho-1-naphthylazo)-1-naphthol-4-sulphonic acid, disodium salt
* Tertracid Red CA
* Tertrochrome Blue FB
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,179,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,179,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil,
France) V.1- 1943- Volume(issue)/page/year: 15,402,1957
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,179,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,179,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 19,413,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 74 gm/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,179,1967
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,289,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,289,1978
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 300 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 300 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
13,133,1989
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,83,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,83,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1431
No. of Facilities: 92 (estimated)
No. of Industries: 3
No. of Occupations: 14
No. of Employees: 1771 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1431
No. of Facilities: 2819 (estimated)
No. of Industries: 39
No. of Occupations: 49
No. of Employees: 38995 (estimated)
No. of Female Employees: 8194 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine
reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-220,82
*** END OF RECORD ***