*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QJ1047000
CHEMICAL NAME           : 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-,
                          sodium salt, L-(-)-
CAS REGISTRY NUMBER     : 26159-34-2
LAST UPDATED            : 199806
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C14-H14-O3.Na
MOLECULAR WEIGHT        : 253.27
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * L-(-)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
   * 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (R)-
   * Naproxen sodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 600 mg/kg/30D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 142,524,1988
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2464 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 36(1,pt2),147,1997
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 20 mg/kg
SEX/DURATION            : female 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 27,505,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 500 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 38,238,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5640
       No. of Facilities: 8 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 239 (estimated)
       No. of Female Employees: 157 (estimated)

 
                            *** END OF RECORD ***