*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ6825000
CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,
3-hydroxy-4-(2,4-xylylazo)-, disodium salt
CAS REGISTRY NUMBER : 3761-53-3
LAST UPDATED : 199707
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C18-H14-N2-O7-S2.2Na
MOLECULAR WEIGHT : 480.44
WISWESSER LINE NOTATION : L66J BNUNR B1 D1& CQ DSWQ HSWQ &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acetacid Red J
* Acidal Ponceau G
* Acid Leather Red KPR
* Acid Leather Red P2R
* Acid Leather Scarlet IRW
* Acid Ponceau R
* Acid Ponceau 2RL
* Acid Ponceau Special
* Acid Red 26
* Acid Scarlet
* Acid Scarlet 2B
* Acid Scarlet 2BN
* Acid Scarlet 2R
* Acid Scarlet 2R For Lakes
* Acid Scarlet 2R FOR Lakes Bluish
* Acid Scarlet 2RL
* Acid Scarlet 2RN
* Acilan Ponceau RRL
* Ahcocid Fast Scarlet R
* Aizen Ponceau RH
* Amacid Lake Scarlet 2R
* Amacid Scarlet 2R
* Brilliant Ponceau G
* Calcocid 2RIL
* Calcocid Scarlet 2R
* Calcocid Scarlet 2RIL
* Calcolake Scarlet 2R
* Certicol Ponceau MXS
* Cerven kysela 26
* Cerven potravinarska 5
* C.I. 79
* C.I. 16150
* C.I. Acid Red 26
* C.I. Acid Red 26, disodium salt
* C.I. Food Red 5
* Colacid Ponceau Special
* Comacid Scarlet 2R
* D&C Red No. 5
* 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulfonic acid,
disodium salt
* 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulphonic acid,
disodium salt
* Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulfonate
* Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulphonate
* Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulfonic acid
* Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulphonic acid
* Edicol Ponceau RS
* Edicol Supra Ponceau R
* Fenazo Scarlet 2R
* Food Red No. 101
* Hexacol Ponceau MX
* Hexacol Ponceau 2R
* Hidacid Scarlet 2R
* Hispacid Ponceau R
* 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulfonic acid, disodium salt
* 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulphonic acid, disodium salt
* Java Ponceau 2R
* Kiton Ponceau R
* Kiton Ponceau 2R
* Kiton Scarlet 2RC
* Lake Ponceau
* Lake Scarlet R
* Lake Scarlet 2RBN
* Naphthalene Lake Scarlet R
* Naphthalene Scarlet R
* Naphthazine Scarlet 2R
* Neklacid Red RR
* New Ponceau 4R
* Paper Red HRR
* Pas kwasowy 2 RL
* Pigment Ponceau R
* Ponceau BNA
* Ponceau de xylidine
* Ponceau FR
* Ponceau G
* Ponceau GR
* Ponceau J
* Ponceau MX
* Ponceau NR
* Ponceau PXM
* Ponceau R
* Ponceau 2R
* Ponceau R (biological stain)
* Ponceau 2R (biological stain)
* Ponceau 2RE
* Ponceau Red
* Ponceau Red R
* Ponceau 2R Extra A Export
* Ponceau RG
* Ponceau 2RL
* Ponceau RS
* Ponceau RR
* Ponceau RR Type 8019
* Ponceau 2RX
* Ponceau xylidine (biological stain)
* 1695 Red
* Red For Lakes J
* Red No. 503
* Scarlet R
* Scarlet 2R
* Scarlet 2RB
* Scarlet 2RL bluish
* Scarlet RRA
* Schultz No. 95
* Tertracid Ponceau 2R
* Xylidine Ponceau
* Xylidine Ponceau 3RS
* Xylidine Red
* 1-Xylylazo-2-naphthol-3,6-disulfonic acid, disodium salt
* 1-(2,4-Xylylazo)-2-naphthol-3,6-disulphonic acid, disodium salt
* 1-Xylylazo-2-naphthol-3,6-disulphonic acid, disodium salt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23160 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 21,65,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - antipsychotic
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1530 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45 gm/kg/90D-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Endocrine - changes in spleen weight
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 136 gm/kg/81W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 6,591,1968
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 gm/kg/52W
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
10,653,1956
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment
Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
Volume(issue)/page/year: 49,1970,1982
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 300 umol/L
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 12,298,1971
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 63 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 108,225,1983
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,189,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,189,1975
IARC Cancer REIEW:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M3143
No. of Facilities: 212 (estimated)
No. of Industries: 4
No. of Occupations: 6
No. of Employees: 2142 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M3143
No. of Facilities: 131 (estimated)
No. of Industries: 3
No. of Occupations: 4
No. of Employees: 1200 (estimated)
No. of Female Employees: 874 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***