*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BP5775000
CHEMICAL NAME           : Ammonium,
                          (3-cyclohexyl-3-hydroxy-3-phenylpropyl)triethyl-,
                          iodide
CAS REGISTRY NUMBER     : 125-99-5
LAST UPDATED            : 198806
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H36-N-O.I
MOLECULAR WEIGHT        : 445.48
WISWESSER LINE NOTATION : L6TJ AXQR&2K2&2&2 &Q &I
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzenepropanaminium, gamma-cyclohexyl-N,N,N-triethyl-gamma-hydroxy-,  
   iodide
   * 921 C
   * Claviton
   * 1-Cyclohexyl-3-diethylamino-1-phenyl-1-propanol ethiodide
   * (3-Cyclohexyl-3-hydroxy-3-phenylpropyl)triethylammonium iodide
   * gamma-Cyclohexyl-N,N,N-triethyl-gamma-hydroxybenzenepropanaminium iodide
   * 3-Diethylamino-1-cyclohexyl-1-phenyl-1-propanol ethiodide
   * alpha-(2-Diethylaminoethyl)-alpha-phenylcyclohexanemethanol ethiodide
   * 3-Diethylamino-1-phenyl-1-cyclohexyl-1-propanol ethiodide
   * Pathilon
   * Propethonum
   * Propethonum iodide
   * Tridihexethide
   * Tridihexethyl iodide
   * Tridihexide
   * Trihexethyl iodide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - ganglion blocker
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,250,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - ganglion blocker
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,250,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 570 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - ganglion blocker
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,250,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   53,84S,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   53,84S,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - ganglion blocker
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,250,1962
 
                            *** END OF RECORD ***