*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : BP3675000
CHEMICAL NAME : Ammonium,
(9-(o-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-yl
idene)diethyl-, chloride
CAS REGISTRY NUMBER : 81-88-9
LAST UPDATED : 199710
DATA ITEMS CITED : 29
MOLECULAR FORMULA : C28-H31-N2-O3.Cl
MOLECULAR WEIGHT : 479.06
WISWESSER LINE NOTATION : T C666 BO EYJ EUK2&2 IR BVQ& MN2&2 &Q &G
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acid Brilliant Pink B
* ADC Rhodamine B
* Aizen Rhodamine BH
* Akiriku Rhodamine B
* Aizen Rhodamine BHC
* Basic Violet 10
* Brilliant Pink B
* Calcozine Red BX
* Calcozine Rhodamine BXP
* 9-o-Carboxyphenyl-6-diethylamino-3-ethylimino-3-isoxanthene,
3-ethochloride
* (9-(o-Carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)
diethylammonium chloride
* Cerise Toner X1127
* C.I. 749
* C.I. 45170
* C.I. Basic Violet 10
* C.I. Food Red 15
* Cogilor Red 321.10
* Cosmetic Brilliant Pink Bluish D Conc
* D & C Red No.19
* Diabasic Rhodamine B
* Edicol Supra Rose B
* Edicol Supra Rose BS
* Elcozine Rhodamine B
* Eriosin Rhodamine B
* FD&C Red No. 19
* Food Red 15
* Geranium Lake N
* Hexacol Rhodamine B Extra
* Ikada Rhodamine B
* Iragen Red L-U
* Mitsui Rhodamine BX
* 11411 Red
* Red No. 213
* Rheonine B
* Rhodamine B
* Rhodamine B 20-7470
* Rhodamine BA
* Rhodamine BA Export
* Rhodamine B chloride
* Rhodamine B Extra
* Rhodamine B Extra M 310
* Rhodamine B Extra S
* Rhodamine BF
* Rhodamine B500
* Rhodamine B500 hydrochloride
* Rhodamine BN
* Rhodamine BS
* Rhodamine BX
* Rhodamine BXL
* Rhodamine BXP
* Rhodamine FB
* Rhodamine Lake Red B
* Rhodamine O
* Rhodamine, tetraethyl-
* Rhodamine S
* Sicilian Cerise Toner A-7127
* Symulex Magenta F
* Symulex Pink F
* Symulex Rhodamine B Toner F
* Takaoka Rhodamine B
* Tetraethyldiamino-o-carboxyphenyl xanthenyl chloride
* Tetraethylrhodamine
* Violet zasadita 10
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council,
Chemical-Biological Coordination Center, Review. (Washington, DC)
Volume(issue)/page/year: 5,8,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008
Paris, France) V.1- 1978- Volume(issue)/page/year: 1,23,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,696,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 887 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008
Paris, France) V.1- 1978- Volume(issue)/page/year: 1,23,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 144 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
60LFAC "Recent Advances of Chemistry and Molecular Biology in Cancer
Research, Insternational Symposium on Recent Advances of Chemistry and
Molecular Biology in Cancer Research, Held in Beijing/China, July 23rd-26th,
1991" Dai Qianhuan, Margaret-Ann Armour and Zheng Qingying eds. Science
Press (Beijing) 1993 Volume(issue)/page/year: -,281,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OKEHDW Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Koshu Eisei Hen.
Research Reports of the Oaka Prefectural Institute of Public Health, Public
Health Section. (Osaka-furitsu Koshu Eisei Kenkyusho, 1-3-69 Nakamichi,
Higashinari-ku, Osaka, 537, Japan) No.3- 1966- Volume(issue)/page/year:
(3),185,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50400 mg/kg/12W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,696,1961
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 110 mg/kg/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 7(2),34,1963
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3600 mg/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
47,51,1956
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3870 mg/kg/68W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75,
1907-84. For publisher information, see JJCREP. Volume(issue)/page/year:
46,369,1955
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 60 mg/kg
SEX/DURATION : female 7-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 40,143,1989
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,181,1979
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 25 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year:
87,295,1953
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 900 umol/plate
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB
37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year:
87,295,1953
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 mg/L
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 4,41,1980
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Mammal - species unspecified Fibroblast
DOSE/DURATION : 2 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,211,1981
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,221,1978
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 16,221,1978
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84376
No. of Facilities: 3759 (estimated)
No. of Industries: 38
No. of Occupations: 37
No. of Employees: 40674 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84376
No. of Facilities: 12726 (estimated)
No. of Industries: 91
No. of Occupations: 88
No. of Employees: 198323 (estimated)
No. of Female Employees: 75440 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; B
subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***