*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BD9000000
CHEMICAL NAME           : Ambisome
SUBSTANCE DEFINITION :
   A lyophilized preparation of liposomal amphotericin B
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   28,(suppl B),49,1991
LAST UPDATED            : 199806
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   28(Suppl B),49,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >175 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   28(Suppl B),49,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg/30D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
   Related to Chronic Data - death
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   28(Suppl B),49,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 mg/kg/13W-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - other changes
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 36(1,pt2),275,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1050 mg/kg/14D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   JACHDX Journal of Antimicrobial Chemotherapy.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1975-  Volume(issue)/page/year:
   28(Suppl B),49,1991
 
                            *** END OF RECORD ***