*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9426040
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-((
                          2,3,6-trideoxy-
                          3-(4-morpholinyl)-alpha-lyxo-hexopyranosyl)oxy)-6,8,1
                          1-trihydroxy-, hydrochloride, (8S-cis)-
CAS REGISTRY NUMBER     : 89196-04-3
LAST UPDATED            : 199303
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C31-H35-N-O12.Cl-H
MOLECULAR WEIGHT        : 650.13
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3'-Deamino-3'-(4-morpholinyl)oxorubicin
   * Morpholinodoxorubicin
   * NSC-354646
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Musculoskeletal - other changes
   Nutritional and Gross Metabolic - dehydration
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB91-211144
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 90 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Musculoskeletal - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB91-211144
 
                            *** END OF RECORD ***