*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9297370
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          7,8,9,10-tetrahydro-8-acetyl-10-((3-amino-2,3,6-tride
                          oxy-alpha-L-lyxo-
                          hexopyranosyl)oxy)-1-methoxy-6,8,11-trihydroxy-,
                          8-cyclohexylidenehydrazone, (8S-cis)-
CAS REGISTRY NUMBER     : 107283-03-4
LAST UPDATED            : 199609
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C33-H39-N3-O9
MOLECULAR WEIGHT        : 621.75
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Rubomycin 13-cyclohexilidene hydrazone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,42,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,42,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,42,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg/20D-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya.  Antibiotics and Medical
   Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32,
   1985-1987  Volume(issue)/page/year: 32,42,1987
 
                            *** END OF RECORD ***