*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9282600
CHEMICAL NAME           : 1-Naphthacenecarboxylic acid,
                          1,2,3,4,6,11-hexahydro-6,11-dioxo-2-ethyl-2,5,7,10-
                          tetrahydroxy-4-((O-2,3,6-trideoxy-alpha-L-glycero-hex
                          opyranosyl-(1-4)-O-2, 6-dideoxy-alpha-
                          L-lyxo-hexopyranosyl-(1-4)
                          2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyr
                          anosyl) oxy)-, methyl ester
CAS REGISTRY NUMBER     : 64474-89-1
LAST UPDATED            : 198806
DATA ITEMS CITED        : 4
WISWESSER LINE NOTATION : L E6 C666 BV MVT&&&J FVO1 GQ G2 KQ OQ RQ IO- FT6OTJ
                          B1 DN1&1 CO- FT6OTJ B1 DQ CO- FT6OTJ B1 C
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic MA 144M2
   * 1-Hydroxy MA144 M1
   * MA144 M2
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 31,78-92,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 31,78-92,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 460 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 48 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
                            *** END OF RECORD ***