*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9282400
CHEMICAL NAME           : 1-Naphthacenecarboxylic acid,
                          1,2,3,4,6,11-hexahydro-6,11-dioxo-2-ethyl-2,5,7,10-
                          tetrahydroxy-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-
                          ((2R-trans)-tetrahydr o-6-methyl-5-oxo-
                          tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo
                          -hexopyranosyl)-3-(di methylamino)-alpha
                          -L-lyxo-hexopyranosyl)oxy)-, methyl ester,
                          (1R-(1-alpha,2-beta,4-beta))-
CAS REGISTRY NUMBER     : 34044-10-5
LAST UPDATED            : 198512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C42-H53-N-O16
MOLECULAR WEIGHT        : 827.96
WISWESSER LINE NOTATION : L E6 C666 BV MVT&&&J DQ HQ H2 IVO1 OQ RQ FO- FT6OTJ
                          B1 DN1&1 CO- FT6OTJ B1 DQ CO- FT6O CVTJ B1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic MA 144A2
   * Cinerubin A
   * Cinerubine A
   * MA-144A2
   * Rhodirubin C
   * Ryemycin-B2
   * Tauromycetin-IV
   * Tavromycetin-IV
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 3,94,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 310 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 36 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
                            *** END OF RECORD ***