*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9279000
CHEMICAL NAME           : 1-Naphthacenecarboxylic acid,
                          4-(((2''',3''-anhydro)-O-3,6-dideoxy-alpha-L-erythro-
                          hexopyranosyl-(1-4)-2,3,6-trideoxy-3-(dimethylamino)-
                          alpha-L-lyxo-hexopyra nosyl)oxy)-2-
                          ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-di
                          oxo-, methyl ester, (1R-(1-alpha, 2-beta,4-beta))-
CAS REGISTRY NUMBER     : 57596-79-9
LAST UPDATED            : 199107
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C42-H51-N-O15
MOLECULAR WEIGHT        : 809.94
COMPOUND DESCRIPTOR     : Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Aclacinomycin B
   * Antibiotic MA 144B1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 28,830,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 28,830,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIGODN Yiyao Gongye.  Pharmaceutical Industry.  (c/o Shanghai Yiyao Gongye
   Yanjiuyuan, 1320 Beijing- xilu, Shanghai 200040, Peop. Rep. China) Beginning
   history not known.  Volume(issue)/page/year: 17,72,1986
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 620 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 62 nmol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 34,1596,1981
 
                            *** END OF RECORD ***