*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9275000
CHEMICAL NAME           : 2-Naphthacenecarboxamide,
                          4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-
                          3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
CAS REGISTRY NUMBER     : 914-00-1
LAST UPDATED            : 199506
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H22-N2-O8
MOLECULAR WEIGHT        : 442.46
WISWESSER LINE NOTATION : L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1
                          KQ MU1 RQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 6-Deoxy-6-demethyl-6-methylene-5-oxytetracycline
   * GS-2876
   * Methacycline
   * Methacycline amphoteric
   * Methacycline base
   * 6-Methylene-5-hydroxytetracycline
   * 6-Methylene-5-oxytetracycline
   * Oxytetracycline, 6-methylene-
   * Rondomycin
   * Tri-methacycline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 660 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 3750 ug/L
REFERENCE :
   BCPHBM British Journal of Clinical Pharmacology.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.1-    1974-  Volume(issue)/page/year:
   16,127,1983

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X1538
       No. of Facilities: 11 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 1150 (estimated)
       No. of Female Employees: 591 (estimated)

 
                            *** END OF RECORD ***