*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QE3950000
CHEMICAL NAME           : Morpholine, 2-((2-ethoxyphenoxy)methyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 35604-67-2
LAST UPDATED            : 199209
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C13-H19-N-O3.Cl-H
MOLECULAR WEIGHT        : 273.79
WISWESSER LINE NOTATION : T6M DOTJ C1OR BO2 &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 2-((o-Ethoxyphenoxy)methyl)morpholine hydrochloride
   * 2-((2-Ethoxyphenoxy)methyl)morpholine hydrochloride
   * 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride
   * 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine hydrochloride
   * ICI 58,834
   * Vicilan
   * Viloxacina clorhidrato
   * Viloxazine hydrochloride
   * Vivalan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 25 mg/kg/6D
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,96,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - sleep
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 4,83,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 4,83,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 162 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 35,812,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 4,83,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 22,385,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 162 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 35,812,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 4,83,1976

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DRUGAY Drugs. International Journal of Current Therapeutics and Applied
   Pharmacology Reviews.  (ADIS Press International Inc., Suite B-30, Oxford
   Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047)  V.1- 1971- 
   Volume(issue)/page/year: 13,401,1977

 
                            *** END OF RECORD ***