*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QE3477835
CHEMICAL NAME           : 4-Morpholineethanamine,
                          N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 25953-17-7
LAST UPDATED            : 199707
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H22-N4-O.2Cl-H
MOLECULAR WEIGHT        : 371.35
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AG 620
   * AGR 620
   * AGR 1240
   * Cantor
   * 30038CM
   * N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine  
   dihydrochloride
   * Minaprine dihydrochloride
   * Morpholine, 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)-,  
   dihydrochloride
   * 3-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 32,824,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4508720
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4823 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Endocrine - changes in thymus weight
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 24,1894,1990
 
                            *** END OF RECORD ***