*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD2975000
CHEMICAL NAME           : Morphinan,
                          6,7,8,14-tetradehydro-4,5-alpha-epoxy-3,6-dimethoxy-1
                          7-methyl-
CAS REGISTRY NUMBER     : 115-37-7
LAST UPDATED            : 199709
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H21-N-O3
MOLECULAR WEIGHT        : 311.41
WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX HO PN GH&&&TTJ FO1 JO1 P1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-,  
   (5-alpha)-
   * Paramorphine
   * Thebain
   * Thebaine
   * (-)-Thebain
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 114 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (4),20,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (4),20,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 6,755,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZNAE "Public Health Reports, Supplement."  (Washington, DC)
   Volume(issue)/page/year: 138,31,1938
 
                            *** END OF RECORD ***