*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD2845000
CHEMICAL NAME           : Morphinan-6-alpha-one,
                          4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)-,
                          bis(hydrogentartrate)
CAS REGISTRY NUMBER     : 74037-65-3
LAST UPDATED            : 197905
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H28-N2-O4.2C4-H6-O6
MOLECULAR WEIGHT        : 696.73
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4,5-alpha-Epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-one  
   bis(hydrogentartrate)
   * 3-Morpholylaethyl-dihydro-morphinon (bis-hydrogentartrat)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,325,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,325,1958
 
                            *** END OF RECORD ***