*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD2163000
CHEMICAL NAME           : 9-alpha,13-alpha,14-alpha-Morphinan-6-one,
                          7,8-didehydro-3,7-dimethoxy-4-hydroxy-17-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 6080-33-7
LAST UPDATED            : 198803
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C19-H23-N-O4.Cl-H
MOLECULAR WEIGHT        : 365.89
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   7,8-Didehydro-3,7-dimethoxy-4-hydroxy-17-methyl-9-alpha,13-alpha,14-alph
     a-morphinan-6-one HCl
   * Sinomenine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4830 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   52,157,1956
 
                            *** END OF RECORD ***