*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QC7874300
CHEMICAL NAME           : Morphinan-6-alpha,14-diol,
                          7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-,
                          14-phenylacetate, hydrochloride
CAS REGISTRY NUMBER     : 103443-77-2
LAST UPDATED            : 199507
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C26-H27-N-O5.Cl-H
MOLECULAR WEIGHT        : 470.00
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Codeine, 14-hydroxy-, 14-phenylacetate, hydrochloride
   * 14-Phenylacetoxycodeine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,174,1964
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 220 mg/kg
SEX/DURATION            : female 9-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny.  Bulletin of
   Experimental Biology and Medicine.  For English translation, see BEXBAN.
   (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 118(8),154,1994
 
                            *** END OF RECORD ***