*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QC7874200
CHEMICAL NAME           : Morphinan-6-alpha,14-diol,
                          7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-,
                          14-nicotinate, dihydrochloride
CAS REGISTRY NUMBER     : 103405-28-3
LAST UPDATED            : 198806
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C24-H24-N2-O5.2Cl-H
MOLECULAR WEIGHT        : 493.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Codeine, 14-hydroxy-, 14-nicotinate, dihydrochloride
   * 14-Nicotinoyloxycodeine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,174,1964
 
                            *** END OF RECORD ***