*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PB9200000
CHEMICAL NAME           : 7,9a-Methano-9aH-cyclopenta(b)heptalene-2,4,8,11,11a,
                          12(1H)-hexol, dodecahydro- 1,1,4,8-tetramethyl-,
                          6,12-diacetate,
                          (2S,3as,4R,4ar,7R,8R,9as,11R,11aR,12R)-
CAS REGISTRY NUMBER     : 30460-34-5
LAST UPDATED            : 199806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H38-O8
MOLECULAR WEIGHT        : 454.62
WISWESSER LINE NOTATION : L E5 B765 A 1B P BXTJ AOV1 DQ EQ F1 F1 GQ JOV1 J1 OQ
                          O1
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * 6-Acetyl-grayanotoxin I
   * 6-O-Acetyl grayanotoxin 1
   * Grayanotoxin III 6,14-diacetate
   * Rhodojaponin IV
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   35,303,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   44,259,1980
 
                            *** END OF RECORD ***