*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PA8400000
CHEMICAL NAME : Methane, dichlorofluoro-
CAS REGISTRY NUMBER : 75-43-4
BEILSTEIN REFERENCE NO. : 1731041
REFERENCE : 4-01-00-00039 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 40
MOLECULAR FORMULA : C-H-Cl2-F
MOLECULAR WEIGHT : 102.92
WISWESSER LINE NOTATION : GYGF
COMPOUND DESCRIPTOR : Reproductive Effector
SYNONYMS/TRADE NAMES :
* Algofrene type 5
* Arcton 7
* CFC-21
* Dichlorofluoromethane
* Dichloromonofluoromethane
* Dwuchlorofluorometan
* Fluorocarbon 21
* Fluorodichloromethane
* Freon 21
* Genetron 21
* FC-21
* Racon 21
* Refrigerant 21
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 49900 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,187,1986
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >800 gm/m3/2H
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 20(11),38,1976
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 pph/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1967- Volume(issue)/page/year: 1,197,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 pph/6H/2W-I
TOXIC EFFECTS :
Liver - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
41(1),199,1977
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1000 ppm/6H/90D-I
TOXIC EFFECTS :
Skin and Appendages - hair
Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
41(1),200,1977
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1 pph/3.5H/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 5000 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520832
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 1 pph/3.5H/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1 pph/3.5H/4W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - fatty liver degeneration
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1 pph/6H
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
45,293,1978
*** REVIEWS ***
ACGIH TLV-TWA 42 mg/m3 (10 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1000 ppm (4200 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,81,1971
OSHA PEL (Gen Indu):8H TWA 1000 ppm (4200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1000 ppm (4200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1000 ppm (4200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1000 ppm (4200 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 10 ppm (45 mg/m3) JAN 1993
OEL-BELGIUM:TWA 10 ppm (42 mg/m3) JAN 1993
OEL-DENMARK:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-FINLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993
OEL-FRANCE:TWA 10 ppm (40 mg/m3) JAN 1993
OEL-GERMANY:TWA 10 ppm (45 mg/m3) JAN 1993
OEL-HUNGARY:STEL 40 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 10 ppm (42 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1000 ppm (4200 mg/m3) JAN 1993
OEL-POLAND:TWA 2000 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993
OEL-TURKEY:TWA 1000 ppm (4200 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 10 ppm (40 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO DICHLOROMONOFLUOROMETHANE-air:10H TWA 10 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 24235
No. of Facilities: 4131 (estimated)
No. of Industries: 44
No. of Occupations: 56
No. of Employees: 43521 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 24235
No. of Facilities: 935 (estimated)
No. of Industries: 8
No. of Occupations: 13
No. of Employees: 12182 (estimated)
No. of Female Employees: 1640 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Dichlorofluoromethane, 2516
*** END OF RECORD ***