*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PB4375000
CHEMICAL NAME : Methanethiol
CAS REGISTRY NUMBER : 74-93-1
BEILSTEIN REFERENCE NO. : 1696840
REFERENCE : 4-01-00-01273 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 36
MOLECULAR FORMULA : C-H4-S
MOLECULAR WEIGHT : 48.11
WISWESSER LINE NOTATION : SH1
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Mercaptan methylique
* Mercaptomethane
* Methaanthiol
* Methanethiol
* Methanthiol
* Methvtiolo
* Methylmercaptaan
* Methyl mercaptan
* Metilmercaptano
* RCRA waste number U153
* Thiomethanol
* Thiomethyl alcohol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 675 ppm
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - hypermotility, diarrhea
Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
LacHB# Personal Communication from H.B. Lackey, Chemical Products Div.,
Crown Zellerbach, Camas, WA 98607, June 9, 1978 Volume(issue)/page/year:
09JUN1978
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6530 ug/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(6),46,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 60670 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 16(6),46,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17 ppm/7H/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
Endocrine - changes in spleen weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 8,71,1981
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 99 pph/6M (Continuous)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,286,1974
*** REVIEWS ***
ACGIH TLV-TWA 0.98 mg/m3 (0.5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.5 ppm (1 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,167,1971
OSHA PEL (Gen Indu):CL 10 ppm (20 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 ppm (1 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 10 ppm (20 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.5 ppm (0.98 mg/m3) JAN 1993
OEL-DENMARK:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.5 ppm (1 mg/m3);STEL 1.5 ppm (3 mg/m3) JAN 1993
OEL-FRANCE:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL-GERMANY:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL-HUNGARY:STEL 1 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 10 ppm (20 mg/m3) JAN 1993
OEL-RUSSIA:STEL 0.8 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 ppm (1 mg/m3);STEL 1 ppm (2 mg/m3) JAN 1993
OEL-THAILAND:TWA 10 ppm (20 mg/m3) JAN 1993
OEL-TURKEY:TWA 10 ppm (20 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 ppm (1 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO METHANETHIOL-air:CL 0.5 ppm/15M
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 45850
No. of Facilities: 11 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 357 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 45850
No. of Facilities: 147 (estimated)
No. of Industries: 7
No. of Occupations: 25
No. of Employees: 6192 (estimated)
No. of Female Employees: 380 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Mercaptans, 2542
OSHA ANALYTICAL METHOD #26
*** END OF RECORD ***