*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PB1800000
CHEMICAL NAME           : Methanesulfonic acid,
                          2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester
CAS REGISTRY NUMBER     : 61866-12-4
LAST UPDATED            : 198806
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C5-H10-Cl-N3-O5-S
MOLECULAR WEIGHT        : 259.69
WISWESSER LINE NOTATION : WS1&O1MVNNO&2G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 2-(3-(2-Chlorathyl)-3-nitrosoureido)athylmethansulfonat
   * 2-(3-(2-Chloroethyl)3-nitrosoureido)ethyl methane sulfonate
   * Cnuems
   * Ethylmethanesulfonato-cnu
   * NSC-294896
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   VDGIA2 Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin.  (J.F.
   Bergmann Verlag, Agnes-Bernauer-Platz 8, D-8000 Munich 21, Fed. Rep. Ger.)
   V.33-52, 1921-40; V.54-    1948-  Volume(issue)/page/year: 85,1293,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13800 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Gastrointestinal - ulceration or bleeding from stomach
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 37,177,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 umol/L/16H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,45,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
   
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion

 
                            *** END OF RECORD ***