*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PA5250000
CHEMICAL NAME : Methane, bromochloro-
CAS REGISTRY NUMBER : 74-97-5
BEILSTEIN REFERENCE NO. : 1730801
REFERENCE : 4-01-00-00074 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 40
MOLECULAR FORMULA : C-H2-Br-Cl
MOLECULAR WEIGHT : 129.39
WISWESSER LINE NOTATION : G1E
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Chlorobromomethane
* Halon 1011
* Methylene chlorobromide
* Mil-B-4394-B
* Mono-chloro-mono-bromo-methane
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,390,1969
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28800 ppm/15M
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - tremor
REFERENCE :
MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports.
(Army Chemical Center, Edgewood Arsenal, MD) Volume(issue)/page/year:
#113,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4300 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,382,1947
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 12030 mg/m3/7H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA)
V.18-31, 1936-49. For publisher information, see AEHLAU.
Volume(issue)/page/year: 29,382,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD-A062-138
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1000 ppm/7H/16W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
21,275,1960
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 ppm/6H/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 8,251,1966
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 500 ppm/6H/26W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 8,251,1966
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1000 ppm/7H/16W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
21,275,1960
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 mg/plate
REFERENCE :
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?).
For publisher information, see HPFSDS. Volume(issue)/page/year:
FDA-78-1046,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 13,205,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 13,205,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 5 umol/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 13,205,1987
*** REVIEWS ***
ACGIH TLV-TWA 1060 mg/m3 (200 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 200 ppm (1050 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,50,1971
OSHA PEL (Gen Indu):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 200 ppm (1050 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1300 mg/m3) JAN 1993
OEL-AUSTRIA:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-FINLAND:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1315 mg/m3) JAN 1993
OEL-FRANCE:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-GERMANY:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 200 ppm (1050 mg/m3);STEL 400 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (1050 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 200 ppm (1050 mg/m3);STEL 250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLOROBROMOMETHANE-air:10H TWA 200 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 18250
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 56 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 18250
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 71 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
*** END OF RECORD ***