*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PB0434000
CHEMICAL NAME           : Methanesulfonamide,
                          N-(2-azidoethyl)-N-((8,9-didehydro-6-methylergolin-8-
                          yl)methyl)-, (Z)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 78463-86-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H24-N6-O2-S.C4-H4-O4
MOLECULAR WEIGHT        : 516.63
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-((N-2-Azidoethyl-N-methylsulfonylamino)methyl)-6-methylergol-8-ene  
   maleate
   * GYKI 32887
   * RGH-7825
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   10,753,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 134 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   10,753,1985
 
                            *** END OF RECORD ***