*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OW2350000 CHEMICAL NAME : Mercury, diethyl- CAS REGISTRY NUMBER : 627-44-1 BEILSTEIN REFERENCE NO. : 3902990 REFERENCE : 4-04-00-04427 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 35 MOLECULAR FORMULA : C4-H10-Hg MOLECULAR WEIGHT : 258.73 WISWESSER LINE NOTATION : 2-HG-2 COMPOUND DESCRIPTOR : Organometallic Mutagen Reproductive Effector Human SYNONYMS/TRADE NAMES : * Diethyl mercury *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 1040 ug/m3/14W TOXIC EFFECTS : Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes REFERENCE : CJPEA4 Canadian Journal of Public Health. (Canadian Public Health Assoc., 1335 Carling Ave., Suite 210, Ottawa, ON K1Z 8N8, Canada) V.20- 1929- Volume(issue)/page/year: 34,158,1943 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 51 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,52,1982 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 258 mg/m3 TOXIC EFFECTS : Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(1),100,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,52,1982 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 91 mg/m3 TOXIC EFFECTS : Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(1),100,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 79,579,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 54 ug/m3/17W-I TOXIC EFFECTS : Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(1),100,1973 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1020 ug/m3/24H/16W-C TOXIC EFFECTS : Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(5),8,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE : 6 ug/m3/24H SEX/DURATION : female 16 week(s) pre-mating TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(5),8,1982 ** MUTATION DATA ** TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Inhalation TEST SYSTEM : Rodent - rat DOSE/DURATION : 6 ug/m3/24H REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(5),8,1982 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 40 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 290,281,1993 *** REVIEWS *** ACGIH TLV-TWA 0.01 mg(Hg)/m3; STEL 0.03 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l, Switzerland) V.1- 1963- Volume(issue)/page/year: 76,265,1974 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 42,103,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.001 ppm (0.01 mg(Hg)/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,22,1973 OSHA PEL (Gen Indu):8H TWA 0.01 mg(Hg)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.01 mg(Hg)/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.01 mg(Hg)/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.01 mg(Hg)/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.01 mg(Hg)/m3;STEL 0.02 mg(Hg)/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.01 mg(Hg)/m3 JAN 1993 OEL-RUSSIA:STEL 0.005 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.01 mg(Hg)/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.01 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993 OEL-THAILAND:TWA 0.01 mg/m3;STEL 0.04 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.01 mg(Hg)/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***