*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OW2350000
CHEMICAL NAME           : Mercury, diethyl-
CAS REGISTRY NUMBER     : 627-44-1
BEILSTEIN REFERENCE NO. : 3902990
REFERENCE               : 4-04-00-04427 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 35
MOLECULAR FORMULA       : C4-H10-Hg
MOLECULAR WEIGHT        : 258.73
WISWESSER LINE NOTATION : 2-HG-2
COMPOUND DESCRIPTOR     : Organometallic
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Diethyl mercury
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 1040 ug/m3/14W
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
REFERENCE :
   CJPEA4 Canadian Journal of Public Health.  (Canadian Public Health Assoc.,
   1335 Carling Ave., Suite 210, Ottawa, ON K1Z 8N8, Canada)  V.20-    1929-
   Volume(issue)/page/year: 34,158,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,52,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 258 mg/m3
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(1),100,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,52,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 91 mg/m3
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(1),100,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 79,579,1959
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54 ug/m3/17W-I
TOXIC EFFECTS :
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(1),100,1973
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1020 ug/m3/24H/16W-C
TOXIC EFFECTS :
   Endocrine - changes in adrenal weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(5),8,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 ug/m3/24H
SEX/DURATION            : female 16 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(5),8,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 6 ug/m3/24H
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(5),8,1982
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 290,281,1993

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.01 mg(Hg)/m3; STEL 0.03 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   TOXICOLOGY REVIEW
   JORCAI Journal of Organometallic Chemistry.  (Elsevier Sequoia SA, POB 851,
   CH-1001 Lausanne l, Switzerland)  V.1-    1963-  Volume(issue)/page/year:
   76,265,1974

   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   42,103,1972

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.001 ppm (0.01 mg(Hg)/m3)
   DTLWS* "Documentation of the Threshold Limit Values for Substances in
   Workroom Air," Supplements. For publisher information, see 85INA8.
   Volume(issue)/page/year: 3,22,1973

   OSHA PEL (Gen Indu):8H TWA 0.01 mg(Hg)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.01 mg(Hg)/m3 (skin)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.01 mg(Hg)/m3 (skin)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.01 mg(Hg)/m3 (skin)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
   
   OEL-BELGIUM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
   
   OEL-DENMARK:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
   
   OEL-FINLAND:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
   
   OEL-FRANCE:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.01 mg(Hg)/m3;STEL 0.02 mg(Hg)/m3;Skin JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.01 mg(Hg)/m3 JAN 1993
   
   OEL-RUSSIA:STEL 0.005 mg/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
   
   OEL-THAILAND:TWA 0.01 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
   
   OEL-THAILAND:TWA 0.01 mg/m3;STEL 0.04 mg/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.01 mg(Hg)/m3;Skin JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.01 mg(Hg)/m3;STEL 0.03 mg(Hg)/m3;Skin JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***