*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OV8700000
CHEMICAL NAME           : Mercury,
                          (3-(((3-carboxy-2,2,3-trimethylcyclopentyl)carbonyl)a
                          mino)-2-methoxypropyl) (mercaptoacetato-S)-, disodium
                          salt
CAS REGISTRY NUMBER     : 21259-76-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 25
MOLECULAR FORMULA       : C16-H27-Hg-N-O6-S.2Na
MOLECULAR WEIGHT        : 608.07
WISWESSER LINE NOTATION : L5TJ AVM1YO1&1S-HG-1VQ A1 B1 B1 CVQ &-NA- 2
COMPOUND DESCRIPTOR     : Drug
                          Organometallic
SYNONYMS/TRADE NAMES :
   * N-(gamma-Carboxymethylmercaptomercuri-beta-methoxy)propylcamphoramic acid 
    disodium salt
   * Disodium  
   N-(3-(carboxymethylthiomercuri)-2-methoxypropyl)-alpha-camphoramate
   * Diucardyn sodium
   * Mercaptomerin sodium
   * Sodium mercaptomerin
   * Thiomerin sodium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 8,316,1949
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,149,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,149,1950

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.01 mg(Hg)/m3; STEL 0.03 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
   DTLWS* "Documentation of the Threshold Limit Values for Substances in
   Workroom Air," Supplements. For publisher information, see 85INA8.
   Volume(issue)/page/year: 3,22,1973

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
   
   OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
   
   OEL-DENMARK:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-FRANCE:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
   
   OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
   
   OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3  JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.01 mg(Hg)/m3 JAN 1993
   
   OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3  JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO MERCURY, ORGANO-air:TWA 0.01 mg/m3;STEL 0.03 mg/m3 (Sk)
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5296
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 628 (estimated)
       No. of Female Employees: 314 (estimated)

 
                            *** END OF RECORD ***