*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OV7895000
CHEMICAL NAME           : Mercury,
                          (3-(o-(carboxymethoxy)benzamido)-2-methoxypropyl)hydr
                          oxy-, monosodium salt, compd. with theophylline
CAS REGISTRY NUMBER     : 7681-34-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 25
MOLECULAR FORMULA       : (C13-H17-Hg-N-Na-O6)n.C7-H8-N4-O2
WISWESSER LINE NOTATION : T56 BM DN FNVNVJ F H &622
COMPOUND DESCRIPTOR     : Drug
                          Organometallic
SYNONYMS/TRADE NAMES :
   * Mersalyl with theophylline
   * Mersalyl-theophylline mixt.
   * Salyrgan theophylline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg(Hg)/kg
TOXIC EFFECTS :
   Musculoskeletal - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 40,394,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8 mg(Hg)/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 40,394,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 87 mg(Hg)/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 40,394,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,149,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 11 mg(Hg)/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
   Musculoskeletal - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 40,394,1951

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.1 mg(Hg)/m3 (skin)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3
   DTLWS* "Documentation of the Threshold Limit Values for Substances in
   Workroom Air," Supplements. For publisher information, see 85INA8.
   Volume(issue)/page/year: 3,22,1973

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
   
   OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993
   
   OEL-DENMARK:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-FRANCE:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993
   
   OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993
   
   OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3  JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.01 mg(Hg)/m3 JAN 1993
   
   OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3  JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***