*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OQ2295000
CHEMICAL NAME           : Maytansine,
                          3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-,
                          isovalerate (ester)
CAS REGISTRY NUMBER     : 66547-10-2
BEILSTEIN REFERENCE NO. : 5416771
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C33-H45-Cl-N2-O9
MOLECULAR WEIGHT        : 649.25
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Ansamitocin P-4
   * C-15003 P-4
   * 3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine isovalerate  
   (ester)
   * Maytansinol isovalerate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 625 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #78-130495
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1 ug/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1707,1980
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 4 ug/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1707,1980
 
                            *** END OF RECORD ***