*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OQ2291600
CHEMICAL NAME           : Maytansine, O(sup
                          3)-de(2-(acetylmethylamino)-1-oxopropyl-22-demethyl-
CAS REGISTRY NUMBER     : 77353-66-3
LAST UPDATED            : 199207
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C27-H35-Cl-N2-O8
MOLECULAR WEIGHT        : 551.09
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Antibiotic C 1500 pnd-0
   * 22-Demethylmaytansinol
   * 32-Normaytansinol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #25898
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #80-118490
 
                            *** END OF RECORD ***