*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OO9275000
CHEMICAL NAME : Manganese
CAS REGISTRY NUMBER : 7439-96-5
LAST UPDATED : 199712
DATA ITEMS CITED : 52
MOLECULAR FORMULA : Mn
MOLECULAR WEIGHT : 54.94
WISWESSER LINE NOTATION : MN
COMPOUND DESCRIPTOR : Tumorigen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Colloidal manganese
* Magnacat
* Mangan
* Manganese
* Mangan nitridovany
* Tronamang
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 2300 ug/m3
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - changes in motor activity (specific assay)
Behavioral - muscle weakness
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
27,454,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 180 mg/kg/30D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,217,1981
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
*** REVIEWS ***
ACGIH TLV-TWA 0.2(Mn)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 4,487,1974
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai
Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku,
Tokyo 107, Japan) V.1- 1965- Volume(issue)/page/year: 11,1300,1975
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Mn,1,1973
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year: 24,1,1955
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 5 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,149,1971
OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3, fume
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 5 mg/m3 JAN 1993
OEL-AUSTRALIA:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993
OEL-BELGIUM:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993
OEL-DENMARK:TWA 1 mg/m3 (fume) JAN 1993
OEL-DENMARK:TWA 2.5 mg/m3 JAN 1993
OEL-FINLAND:TWA 1 mg/m3 (fume) JAN 1993
OEL-FINLAND:TWA 2.5 mg/m3 JAN 1993
OEL-FRANCE:TWA 1 mg/m3 (fume) JAN 1993
OEL-GERMANY:TWA 5 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-RUSSIA:STEL 0.2 mg/m3 (fume) JAN 1993
OEL-SWEDEN:TWA 2.5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 1 mg/m3 (fume) JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-THAILAND:TWA 5 mg/m3 JAN 1993
OEL-TURKEY:TWA 5 mg/m3 (fume) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MANGANESE COMPDS (as Mn)-air:TWA 1 mg/m3;STEL 3 mg/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44000
No. of Facilities: 1963 (estimated)
No. of Industries: 29
No. of Occupations: 53
No. of Employees: 19787 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5920
No. of Facilities: 26 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 305 (estimated)
No. of Female Employees: 71 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5992
No. of Facilities: 235 (estimated)
No. of Industries: 9
No. of Occupations: 9
No. of Employees: 4560 (estimated)
No. of Female Employees: 12 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44000
No. of Facilities: 66404 (estimated)
No. of Industries: 316
No. of Occupations: 125
No. of Employees: 756403 (estimated)
No. of Female Employees: 15912 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID-125G
*** END OF RECORD ***