*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OO9163250
CHEMICAL NAME : Manganate(6-),
((N,N'-1,2-ethanediylbis(N-((3-hydroxy-2-methyl-5-((p
hosphonooxy)-methyl)- 4-pyridinyl)methyl)glycinato))
(8-))-, trisodium trihydrogen, (OC-6-13)-
CAS REGISTRY NUMBER : 140678-14-4
LAST UPDATED : 199806
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C22-H24-Mn-N4-O14-P2.3H.3Na
MOLECULAR WEIGHT : 757.38
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Mangafodipir trisodium
* MnDPDP
* Teslascan
* Win 59010
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2196 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ACRAE3 Acta Radiologica. (Acta Radiologica, POB 7449, S10391 Stockholm,
Sweden) V.28- 1987- Volume(issue)/page/year: 38,770,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1439 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
ACRAE3 Acta Radiologica. (Acta Radiologica, POB 7449, S10391 Stockholm,
Sweden) V.28- 1987- Volume(issue)/page/year: 38,770,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2954 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARASA5 Acta Radiologica, Supplementum. (Acta Radiologica, POB 7449, S-10391
Stockholm, Sweden) No.1- 1921- Volume(issue)/page/year: 394,32-52,1994
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1666 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
REFERENCE :
ACRAE3 Acta Radiologica. (Acta Radiologica, POB 7449, S10391 Stockholm,
Sweden) V.28- 1987- Volume(issue)/page/year: 38,770,1997
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 530 mg/kg/10W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Kidney, Ureter, Bladder - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ACRDA8 Acta Radiologica: Diagnosis. (Box 7449, S-10391 Stockholm, Sweden)
New series: V.1- 1963- Volume(issue)/page/year: 38,759,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1596 mg/kg/21D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ACRAE3 Acta Radiologica. (Acta Radiologica, POB 7449, S10391 Stockholm,
Sweden) V.28- 1987- Volume(issue)/page/year: 38,770,1997
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 182 mg/kg
SEX/DURATION : female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ACRDA8 Acta Radiologica: Diagnosis. (Box 7449, S-10391 Stockholm, Sweden)
New series: V.1- 1963- Volume(issue)/page/year: 38,759,1997
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 45945 ug/kg
SEX/DURATION : female 15-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 52,109,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 90889 ug/kg
SEX/DURATION : female 12-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 52,109,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 182 mg/kg
SEX/DURATION : female 9-11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 52,109,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 197 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ACRDA8 Acta Radiologica: Diagnosis. (Box 7449, S-10391 Stockholm, Sweden)
New series: V.1- 1963- Volume(issue)/page/year: 38,759,1997
*** END OF RECORD ***