*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ON4250000
CHEMICAL NAME : Maleic anhydride, polymer with vinyl ether
CAS REGISTRY NUMBER : 27100-68-1
OTHER CAS REGISTRY NOS. : 74621-32-2
LAST UPDATED : 199609
DATA ITEMS CITED : 11
MOLECULAR FORMULA : (C4-H6-O.C4-H2-O3)x
WISWESSER LINE NOTATION : T5VOVJ &1U1O1U1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Divema
* Divinyl ether combined with maleic anhydride (1:2)
* Divinyl ether maleic anhydride copolymer
* 2,5-Furandione, polymer with 1,1'-oxybis(ethene)
* MVE-1
* MVE-2
* MVE-4
* Pyran
* Pyran (copolymer)
* Pyran NSC 46015
* Pyran NSC 46015 D
* Pyran XA 124-177
* Vinyl ether combined with maleic anhydride
* XA 124-177
* XA 146-85-2
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48700 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Liver - other changes
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3812248
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 74 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Liver - other changes
Tumorigenic - active as anti-cancer agent
REFERENCE :
POLMAG Polymer. The Chemistry, Physics and Technology of High Polymers.
(Quadrant Subscription Services Ltd., Oakfield House, Perrymount Rd.,
Haywards Heath, W. Sussex RH16 3DH, UK) V.1- 1960-
Volume(issue)/page/year: 18,461,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >100 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 120 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
39TKAR "Handbook of Cancer Immunology," Waters, H., ed., 5 vols., New York,
Garland STPM Press, 1978 Volume(issue)/page/year: 5,135,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 90 mg/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Related to Chronic Data - changes in testicular weight
REFERENCE :
PCRTDK Progress in Cancer Research and Therapy. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
16,345,1981
*** END OF RECORD ***