*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6780000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-tryp(sup
                          6),des-gly-NH2(sup 10))-, ethylamide
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * (D-Tryp(sup 6),des-gly-NH2(sup 10))-LHRH ethylamide
   * (D-Tryp(sup 6),des-gly-NH2(sup 10))-luteinizing hormone-releasing hormone 
    ethylamide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 300 ug/kg
SEX/DURATION            : male 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 30,585,1984
 
                            *** END OF RECORD ***