*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OK6750000
CHEMICAL NAME : Luteinizing hormone-releasing factor (pig),
6-D-tryptophan-7-(N-methyl-L-leucine)-9-(N-
ethyl-L-prolinamide)-10-deglycinamide-
CAS REGISTRY NUMBER : 66866-63-5
OTHER CAS REGISTRY NOS. : 102586-12-9
67910-57-0
LAST UPDATED : 199706
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C65-H85-N17-O12
MOLECULAR WEIGHT : 1296.67
COMPOUND DESCRIPTOR : Reproductive Effector
Hormone
SYNONYMS/TRADE NAMES :
* Lutrelin
* D-Trp(sup 6)-(N)Me-leu(sup 7)-des-gly(sup 10)-pro(sup 9)-LHRH ethylamide
* WY 40,972
* Wyeth 40972
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 11,113,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3500 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 3500 ng/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 30 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 35 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83.
Volume(issue)/page/year: 6,1,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 250 ug/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
INJFA3 International Journal of Fertility. (Allen Press, 1041 New
Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year:
29,122,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 50 ug/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Primate - monkey
DOSE : 700 ug/kg
SEX/DURATION : male 20 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - other effects on male
Endocrine - androgenic
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 43,115,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 70 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 6 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
*** END OF RECORD ***