*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6600000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-phe(sup
                          2))-(D-ala(sup 6))-
CAS REGISTRY NUMBER     : 54784-44-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C59-H79-N15-O13
MOLECULAR WEIGHT        : 1206.53
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Luteinizing hormone-releasing hormone (pig),  
   2-D-phenylalanine-6-D-alanine-
   * (D-Phe(sup 2))-(D-ala(sup 6))-LHRH
   * (D-Phe(sup 2))-(D-ala(sup 6))-luteinizing hormone-releasing hormone
   * WY-18,185
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3750 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1247,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   IJGOAL International Journal of Gynaecology & Obstetrics.  (Elsevier
   Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland)  V.7-    1969-
   Volume(issue)/page/year: 16,359,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   EDRCAM Endocrine Research Communcations.  (New York, NY)  V.1-9, 1974-83.
   Volume(issue)/page/year: 2,1,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 12500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   EDRCAM Endocrine Research Communcations.  (New York, NY)  V.1-9, 1974-83.
   Volume(issue)/page/year: 2,1,1975
 
                            *** END OF RECORD ***