*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6515000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-leu(sup
                          6),des-gly(sup 10))-, ethylamide
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * D-Leu(sup 6),des-gly(sup 10)-Gnrh ethylamide
   * (D-Leu(sup 6),des-gly(sup 10))-gonadotropin releasing hormone ethylamide
   * (D-Leu(sup 6),des-gly(sup 10))-LHRH ethylamide
   * (D-Leu(sup 6),des-gly(sup 10))-luteinizing hormone-releasing hormone  
   ethylamide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11200 ng/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   30,646,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16800 ng/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 41,309,1984
 
                            *** END OF RECORD ***