*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6500000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-pglu(sup
                          1),D-phe(sup 2),D-trp(sup 3,6))-
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * (D-pGlu(sup 1),D-phe(sup 2),D-trp(sup 3,6))-LHRH
   * (D-pGlu(sup 1),D-phe(sup 2),D-trp(sup 3,6))-lrf
   * (D-pGlu(sup 1),D-phe(sup 2),D-trp(sup 3,6))-luteinizing hormone-releasing 
    hormone
   * (D-Glu(sup 1),D-phe(sup 2),D-trp(sup 3),D-trp(sup 6))-LHRH
   * (D-Glu(sup 1),D-phe(sup 2),D-trp(sup 3),D-trp(sup 6))-luteinizing  
   hormone-releasing hormone
   * Luteinizing hormone-releasing hormone, (D-glu(sup 1),D-phe(sup  
   2),D-trp(sup 3),D-trp(sup 6))-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 87500 ug/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 19,185,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 175 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 19,185,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   LIFSAK Life Sciences.  (Pergamon Press Inc., Maxwell House, Fairview Park,
   Elmsford, NY 10523) V.1-8, 1962-69; V.14-    1974- Volume(issue)/page/year:
   23,869,1978
 
                            *** END OF RECORD ***