*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6376200
CHEMICAL NAME           : Luteinizing hormone-releasing hormone,
                          (N-AC-D-p-F-phe(sup 1)-D-p-Cl-phe(sup 2)- D-trp(sup
                          3,6)-D-ala(sup 10))-
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * (N-Ac-D-p-F-phe(sup 1)-D-p-Cl-phe(sup 2)-D-trp(sup 3,6)-D-ala(sup  
   10))-LHRH
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 19040 ug/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ARANDR Archives of Andrology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   11,89,1983
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 37500 ng/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 100,915,1981
 
                            *** END OF RECORD ***