*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6369000
CHEMICAL NAME           : Luteinizing hormone, rabbit antibovine serum
LAST UPDATED            : 198910
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Rabbit antibovine LH serum
   * Rabbit antibovine luteinizing hormone serum
   * Serum, rabbit antibovine luteinizing hormone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 7-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 20,679,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12500 mg/kg
SEX/DURATION            : female 1-5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Maternal Effects - parturition
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   14,8,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13500 mg/kg
SEX/DURATION            : female 13-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 145,334,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13500 mg/kg
SEX/DURATION            : female 13-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - parturition
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 143,422,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Multiple routes
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 3300 ug/kg
SEX/DURATION            : male 12 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   10,453,1974
 
                            *** END OF RECORD ***