*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OJ6605050
CHEMICAL NAME           : Lithospermum callosum Vahl., alkaloidal extract
SUBSTANCE DEFINITION :
   Plant belonging to the family Boraginaceae
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
LAST UPDATED            : 199506
DATA ITEMS CITED        : 4
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Moltikiopsis ciliata (forssk.) extract
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 26,112,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 26,112,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 26,112,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - somnolence (general depressed activity)
   Cardiac - other changes
REFERENCE :
   IJCREE International Journal of Crude Drug Research.  (Swets & Zeitlinger
   B.V., POB 825, 2160 SZ Lisse, Netherlands)  V.20-    1982-
   Volume(issue)/page/year: 26,112,1988
 
                            *** END OF RECORD ***