RTECS NUMBER-OH4725810-Chemical Toxicity Database

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OH4725810
CHEMICAL NAME           : Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate)
CAS REGISTRY NUMBER     : 16846-24-5
OTHER CAS REGISTRY NOS. : 56689-45-3
LAST UPDATED            : 199603
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C42-H69-N-O15
MOLECULAR WEIGHT        : 828.12
WISWESSER LINE NOTATION : T-16-OV KU MUTJ DOV1 EO1 G1VH I1 JQ P1 FO- BT6OTJ CQ
                          DN1&1 F1 EO- FT6OTJ B1 COV1Y1&1 DQ D1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic yl-704 A3
   * Josamycin
   * Kitasamycin A3
   * Leucomycin A3
   * Turimycin A5
   * Yl-704 A3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,364,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,364,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,364,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIPDAD Nihon Daigaku No-juigakubu Gakujutsu Kenkyu Hokoku.  Research Reports
   of the College of Agriculture and Veterinary Medicine, Nihon University. 
   (Nihon Daigaku Nojuigakkai, 34-1 Shimouma, 3-chome, Setagaya-ku, Tokyo 154,
   Japan)  No.1-    1953-  Volume(issue)/page/year: (35),41,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 37,1565,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 780 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 2,85,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,364,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIPDAD Nihon Daigaku No-juigakubu Gakujutsu Kenkyu Hokoku.  Research Reports
   of the College of Agriculture and Veterinary Medicine, Nihon University. 
   (Nihon Daigaku Nojuigakkai, 34-1 Shimouma, 3-chome, Setagaya-ku, Tokyo 154,
   Japan)  No.1-    1953-  Volume(issue)/page/year: (35),41,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 786 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HINAAU Hindustan Antibiotics Bulletin.  (Hindustan Antibiotics, Ltd.,
   Pimpri, Poona, India) V.1-    1958-  Volume(issue)/page/year: 11,26,1969
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg/5W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 22,219,1969
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 21 gm/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 22,219,1969
 
                            *** END OF RECORD ***